The Aviva Premiership club's new Allianz Park home, complete with its artificial playing surface, had been mooted as a possible venue.
But club chairman Nigel Wray told Saracens' official website on Wednesday that the game will be staged at Twickenham.
"We look forward to playing this important match at the home of English rugby, a ground that many of our players know extremely well," Wray said.
"It is absolutely clear that people want to see big teams playing big matches at big stadiums, and that is precisely what we will deliver at Twickenham.
"We did consider the option of playing this showpiece match at Allianz Park, our brand new home stadium in NW4, but, in consultation with local residents and our partners at the London Borough of Barnet, we have decided to settle at the new venue before applying to stage a one-off event with a larger capacity."
Harlequins will host Munster at their Twickenham Stoop home the following day, with the quarter-final line-up completed by Leicester visiting Toulon and Clermont Auvergne hosting Montpellier.
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