Northampton are already eight points behind the Pool Four leaders, and a group stage exit looms large.
To compound Saints' degree of difficulty, Ulster are unbeaten in all competitions this season and they have not suffered a Heineken Cup home defeat since Stade Francais beat them 26-10 four years ago.
The English club are also without their captain Dylan Hartley, who has received a two-week ban after being cited for striking Ulster hooker Rory Best last Friday.
"I think that it stung so much because we were at home and conceded four tries," Northampton's England international full-back Ben Foden said, reflecting on last week's loss.
"The performance let us down, as individuals and as a team. There was no finger-pointing. We sat down and took the blame as a team, and we know we have to make things better.
"It is a big ask to go to Ravenhill and beat an undefeated side, but for us it is about pride, of getting back on track.
"A lot of people will write us off - which is probably a good thing - but we are probably at our most dangerous when teams take us for granted. We will be looking to put in a big performance at Ravenhill."
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.