The 22-year-old Francis is in contention for Saturday's round three clash with Racing Metro at the Stade Yves du Manoir after recovering from a leg injury which has kept him out since he moved to Murrayfield last month from Waikato Chiefs in New Zealand.
Rennie suffered a dislocated shoulder against the All Blacks in Scotland's opening autumn Test on November 11.
Edinburgh head coach Michael Bradley said: "It's obviously disappointing for Ross to be ruled out for these next two rounds.
"However, it's a fantastic opportunity for a new member of our squad to push for a place in the best club rugby competition in the world."
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The Barbarians are one of the top invitational rugby sides with a long history and classic rugby jersey.
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The Lions are ready to get their Australia tour underway. They arrive in Perth on Monday.
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The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.
