The Chiefs suffered a 9-6 defeat to the European champions Leinster in their first Pool Five game last weekend.
It was a remarkable performance as the newcomers were the first team to prevent Leinster from reaching double figures in the Heineken Cup for 26 matches.
Buoyed by their impressive display in Dublin, head coach Rob Baxter has resisted the temptation to make wholesale changes to his line-up.
Baxter's sole change in personnel sees Australia international Dean Mumm handed his first European start in place of James Hanks, who drops to the bench.
Exeter have won their last five European fixtures (in the Challenge Cup) at Sandy Park but Clermont have lost just one of their last five Heineken Cup encounters - a 15-19 defeat to Leinster in last season's semi-final.
The Top 14 outfit have also made one change. With Nathan Hines serving a six-week suspension France international Julien Pierre is called into coach Vern Cotter's second row.
Exeter Chiefs: 15 Luke Arscott, 14 Ian Whitten, 13 Phil Dollman, 12 Jason Shoemark, 11 Matt Jess, 10 Gareth Steenson, 9 Haydn Thomas, 8 Richard Baxter, 7 James Scaysbrook, 6 Tom Johnson, 5 Dean Mumm, 4 Tom Hayes, 3 Carl Rimmer, 2 Simon Alcott, 1 Brett Sturgess.
Replacements:16 Chris Whitehead, 17 Chris Budgen, 18 Ben Moon, 19 James Hanks, 20 Ally Muldowney, 21 Will Chudley, 22 Ignacio Mieres, 23 Sireli Naqelevuki,
Clermont Auvergne: 15 Lee Byrne, 14 Sitiveni Sivivatu, 13 Aurélien Rougerie, 12 Wesley Fofana, 11 Napolioni Nalaga, 10 Brock James, 9 Morgan Parra, 8 Damien Chouly, 7 Julien Bonnaire, 6 Gerhard Vosloo, 5 Julien Pierre, 4 Jamie Cudmore, 3 Davit Zirakashvili, 2 Benjamin Kayser, 1 Thomas Domingo.
Replacements:16 Ti'i Paulo, 17 Vincent Debaty, 18 Daniel Kotze, 19 Loic Jacquet, 20 Elvis Vermeulen, 21 Ludovic Radoslavjevic , 22 David Skrela, 23 Benson Stanley.
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