Worcester boss Richard Hill accepts that his team need "a couple of wins" to move away from the Premiership's danger area.
The Warriors head to title play-off contenders Gloucester on Friday night after suffering four successive league defeats. They are without a Premiership win since Christmas.
And while being dragged into a relegation battle currently being fought by three clubs - Sale Sharks, London Irish and London Welsh - still appears unlikely, it cannot be ruled out.
Ninth-placed Worcester are currently seven points above bottom club Sale, and current form suggests they might struggle to secure anything from a short trip down the M5 to Kingsholm.
"We need a couple of wins to get us away from that bottom area of the table, and we will have to work very hard on Friday to try and get the first of them," Hill said.
"It's a very tough place to go, Kingsholm - a big derby under lights - but we normally perform well in these evening games.
"The players have been in good spirits despite the defeat to Northampton last weekend.
"Gloucester will pose very similar problems to us that Northampton did, and it will be a real challenge to us. Our defence will certainly be tested in the wider areas, as they have got some very sharp players like Jonny May, Charlie Sharples and Rob Cook."
Hill hands number eight Blair Cowan his first Premiership start of the season, while there are also call-ups for Chris Pennell - he replaces injured wing Josh Drauniniu - centre Josh Matavesi and hooker Ed Shervington.
Gloucester show two changes from the side edged out 33-29 by play-off rivals Wasps last weekend, with centre Henry Trinder in for Tim Molenaar and prop Dan Murphy replacing Nick Wood.
"It's very much about keeping the energy in this group of players," Gloucester rugby director Nigel Davies said.
"They worked extremely hard last Sunday up at Wasps and were unlucky not to come away with the win. Over the past two weeks, I've been pleased with the performances that have been put in.
"Worcester are fighting hard in the Premiership to ease clear of the bottom three teams, while we are trying to force our way into the top four. There is a lot at stake for both teams."
Sale, having closed the gap on Irish to a point after pipping London Welsh 26-25 last weekend, are back in action on Friday night when they entertain Premiership champions and current leaders Harlequins.
The Sharks show five changes, including starts for full-back Cameron Shepherd, prop Ross Harrison, hooker Tommy Taylor and lock Kearnan Myall, while Quins head north again without fly-half Nick Evans.
New Zealander Evans was forced out of last weekend's game against Leicester due to an ankle injury, so Ben Botica continues in the number 10 shirt.
Scrum-half Karl Dickson replaces Danny Care, who is on England duty, with captain Nick Easter moving from second-row to back-row instead of an injured Tom Guest and Charlie Matthews starting at lock.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.