England winger Chris Ashton scored two tries for Northampton as Newcastle were dismissed 44-15 at Franklin's Gardens.
Saints centre Tom May also crossed twice - his first two tries for the club - while Russian winger Vasily Artemyev added two more to take his tally to six in three matches since arriving at Northampton following the World Cup.
Ryan Lamb, who was involved in the build-up to the first three tries, contributed 12 points, with two penalties and three conversions, with his replacement Stephen Myler adding a conversion.
Kiwi fly-half Jimmy Gopperth scored all Newcastle's points, with four penalties and a drop goal.
Harlequins cemented their place at the top of the table when they beat Exeter 19-13 at The Stoop.
Quins' victory enabled them to extend their run to nine straight wins in all competitions but they were pushed to the end by a battling Exeter side.
Nick Evans scored 14 points for the home team in what was their toughest test of the season to date.
A controversial late try by centre Brad Barritt and a Owen Farrell touchline conversion gave reigning champions Saracens a last-gasp 19-17 victory to end Gloucester's 22-match winning run at Kingsholm.
It was the only time Saracens led in the match and the result kept them in second place.
Sam Vesty's late penalty gave Bath a 13-12 victory over London Irish in a closely fought encounter at the Madejski Stadium.
Bath dominated the early exchanges and led 5-0 at half-time but Irish started the second half strongly and Tom Homer landed two penalties to edge them ahead 6-5.
Bath regained the lead when Dave Attwood went over in the corner for their second try before Homer booted over his third and fourth penalties to give Irish a 12-10 lead.
But Vesty had the final word with the penalty in the closing minutes following an infringement by Shontayne Hape.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
$29.99
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.