Former Harlequins lock James Percival returns to face his old side as the Warriors look to add a second home win of the season to their opening-day success over Sale.
Dale Rasmussen is brought back into the centres after serving his one-match suspension, while Shaun Perry will take his place at scrum-half after being passed fit.
Partnering him at half-back will be Andy Goode, who needs only three more points to reach 1,500 in total in his Premiership career.
In the pack, Tevita Taumeopeau is promoted from the bench to pack down at prop and Neil Best makes a return at flanker.
Prop Ceri Jones could also play against his former club after he was named among the replacements.
Meanwhile, Harlequins will hope to maintain their unbeaten start to the campaign after naming an unchanged starting XV for the clash.
The only change comes on the bench, where Seb Stegmann returns to the squad after coming back from injury.
Quins have won all three of their opening games, including a 42-6 thrashing of Gloucester last time out, but their opponents have not lost at Sixways for 16 matches in total.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
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The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.