Stephen Myler is handed the fly-half duties in place of Ryan Lamb, while Paul Doran-Jones and Brian Mujati come in to the front row.
While Saints are looking to arrest a run of defeats Sale will be looking to string together a third straight win after victories over London Irish and Wasps.
The Sharks are boosted by the return of captain Sam Tuitupou, who comes on to the bench, with young winger Tom Brady coming in for Charlie Amesbury, although they have been dealt a blow with the news that England flanker Hendre Fourie needs a shoulder operation.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The Barbarians are one of the top invitational rugby sides with a long history and classic rugby jersey.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Lions get ready for their matches with this green training jersey. It's what the players wear. Get in the Gear!
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The Lions are ready to get their Australia tour underway. They arrive in Perth on Monday.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.