Exeter made it two wins out of two as they claimed a 32-15 victory over Newcastle.
The Chiefs claimed a bonus point as they outscored the Falcons by four tries to two to continue the woes of their visitors, who fell to their ninth defeat in a row, stretching back to last season, and so extended their poorest run in the tournament.
Jason Shoemark, Josh Tatupu, Phil Dollman and Sireli Naqelevuki all crossed for the hosts while Tom Catterick and James Fitzpatrick scored Newcastle's tries.
Owen Farrell landed a penalty via both posts with the last kick of the game to earn Saracens a dramatic 28-26 victory over Bath at the Recreation Ground.
The lead changed hands five times in the second half as Farrell's kicking regained the initiative for the defending champions only for Sam Vesty to edge Bath back in front with a penalty six minutes from time.
The drama of the last few minutes saw Neil de Kock have a clearance kick charged down on his line but Bath could not apply the killer blow and Saracens cleared from behind their own posts.
With only seconds left on the clock, the Londoners won turnover ball and Brad Barritt attacked down the left to win the final penalty from referee Greg Garner. Farrell finished with a tally of 23 points.
The hosts won the try count 2-1 thanks to Nick Abendanon and Carl Fearns while James Short crossed for the visitors' score but a losing bonus point will be of little consolation.
Jonny May and Tom Voyce crossed for tries as Gloucester picked up their first win of the season with a comfortable 29-8 victory over Worcester at Kingsholm.
The damage was done in the first half as a breakaway try from centre May and a conversion and four penalties from fly-half Tim Taylor put the Cherry and Whites into a 19-3 half-time lead, Joe Carlisle replying with a penalty for the visitors.
Replacement Freddie Burns added a further penalty and converted Voyce's late try during a scrappy second half as Bryan Redpath's side bounced back from their late defeat at Northampton last weekend.
Dale Rasmussen got a consolation try for Worcester but this was a reality check for boss Richard Hill, as his newly-promoted side came back down to earth with a bump following their win over Sale on the opening day.
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