Shaun Edwards says Wales are braced for "two huge weeks" as the reigning RBS 6 Nations champions embark on a concerted title defence.
England's comfortably-superior points difference makes it a difficult scenario, even if Wales beat their arch-rivals in Cardiff on March 16.
With Italy next on their agenda at Twickenham in six days' time, and Wales facing a testing Murrayfield clash against Scotland 24 hours earlier, the odds heavily favour England.
But Wales, buoyed by successive away victories over France and Italy, have at least put themselves in title contention approaching the tournament's business end.
And their recent Six Nations record - 10 wins from the last 12 starts, including four successive away victories - suggests it would be a fool's game to dismiss them.
"It's all systems go for two huge weeks," Wales assistant coach and defence specialist Edwards said.
"These lads have been absolutely fantastic over the last few years.
"Of the games I've been involved in in the Six Nations - and I honestly believe we are truly judged on the Six Nations - we've only lost one game in the last 11 (Edwards was suspended following an internal incident for the 2011 France Test that Wales lost 28-9).
"If we can make that one in 13, then that has got to be a pretty impressive record.
"I just think the whole of Wales comes alive in the Six Nations. That's not to say we don't want to go to Australia and win, but I do think the whole of Wales comes alive, Six Nations time.
"We started off slowly against Ireland, but the second-half of that game and the last two games, particularly from my department, have been as good as I could expect from a rugby team.
"We have only conceded three defensive points in two matches - the other points (12), have been scrum penalties.
"If we can continue in that form over the next two games, we are in with a chance."
Wales' interim head coach Rob Howley is due to name his starting XV for Scotland on Tuesday, with two changes likely following a 26-9 win in Rome last time out.
Prop Gethin Jenkins is battling to overcome a calf muscle injury - Bath's Paul James would be his replacement - while fit-again lock Alun-Wyn Jones could take over from Andrew Coombs.
Howley must also decide whether or not he recalls last season's Grand Slam skipper Sam Warburton, who was on bench duty against Italy, or retain Justin Tipuric in the number seven shirt.
And if Warburton starts, Howley then has another issue facing him - does he re-install the Cardiff Blues star as captain or retain Ryan Jones, who did a brilliant job leading Wales against France and Italy.
Whatever happens in selection, Wales' fourth win from the last five visits to Edinburgh is by no means guaranteed, especially with Scotland - now coached by former Wales boss Scott Johnson - on a roll after beating Italy and Ireland.
"They've got momentum as well," Edwards added. "It will be two evenly-matched teams going at it, and that's what sport is about.
"They are very resilient, which is a major attribute.
"Every day I wake up I think I have got something to prove, and I am sure Scott is the same because he's a competitor, like I am.
"People like Scott Johnson are good for the game. They get newspaper space, particularly somewhere like Scotland where you get Celtic, Rangers and football being very dominant.
"If people can get headlines for rugby, it's obviously good for the game. We need characters in the game of rugby, and Scott is definitely a character, isn't he."
And the major Scottish threats to Wales should come from their in-form players like full-back Stuart Hogg and scrum-half Greig Laidlaw, who have both emerged as major British and Irish Lions contenders for this summer's Australia tour.
"Sometimes you make slight adjustments to your defence," Edwards said. "You have to be careful of Hogg and his counter-attacking, and both the wings can score tries.
"But if you tinker with it too much you get away from what you are good at. It's about sticking to the basics while having their danger players in mind.
"They've got big powerful ball-carriers in the centre, and I really like their nine (Laidlaw). I think he's a very clever player, a very good rugby player whether he plays nine or 10.
"He lifts his head up and counts numbers that are in front of him."
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