Joe Ajuwa for Ashley Smith on the wing is the only alteration to the back division.
Hooker Dan George is back from injury in place of Greg Bateman, while tight head prop James Tideswell and No 8 Alfie To'oala start in place of Arthur Joly and Daniel Browne respectively.
London Welsh received a boost to their quarter-final hopes earlier in the week when the result of their defeat in Grenoble on December 7 was reversed because the French side had fielded an inelgiable player, Lotu Taukeiaho.
Grenoble were docked the four points they gained from the 20-9 victory and fined 10,000 euros by an independent disciplinary committee, who changed the result of the match to a 28-0 win for London Welsh.
It means the Aviva Premiership newcomers gain five points and move from third to second in Pool 5, now three points above Grenoble and 10 behind group leaders Stade Francais, who beat Cavalieri Prato on Thursday in their round-four fixture.
London Welsh: 15 Tom Arscott, 14 Phillip Mackenzie, 13 James Lewis, 12 Seb Jewell, 11 Joe Ajuwa, 10 Alex Davies, 9 Nick Runciman, 8 Alfie Vaeluaga Toala, 7 Mike Hills, 6 Lee Beach, 5 Matt Corker, 4 Adam Brown, 3 James Tideswell, 2 Greg Bateman, 1 Tom Bristow.
Replacements: 16 Greg Bateman, 17 Billy Moss, 18 Arthur Joly, 19 Mike Denbee, 20 Jon Mills, 21 Matt Keyte, 22 Simon Whatling, 23 Nick Scott.
Grenoble: 15 Fabien Gengenbacher, 14 Florian Ninard, 13 Rida Jaouher, 12 Aloisio Butonidualevu, 11 Viliame Waqaseduadua, 10 Blair Stewart, 9 Valentin Courrent, 8 Flavein Nouhaillaguet, 7 Henri Vanderglas, 6 Jonathan Best, 5 Andrew Farley, 4 Ben Hand, 3 Karim Kouider, 2 Laurent Bouchet, 1 Gregory Fabro.
Replacements: 16 Vincent Campo, 17 Romain David, 18 Feliuaki Taukeiaho, 19 Fabien Alexandre, 20 James Hart, 21 Aaron Bancroft, 22 Jonathan Pelissie, 23 Thibault Rey.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.