After their 34-28 defeat last weekend to Premiership rivals London Irish, Sale have named a strong side for the clash.
Despite the Sharks being bottom of the league standings, Saracens won't be taking anything for granted against a side determined to get back to winning ways.
Sale hand David Seymour the captaincy yet are set to lose Johnny Leota and Richie Gray to the Autumn international programme.
Meanwhile Saracens, who got their LV= Cup campaign off to a winning start last week with a 38-21 victory over Leicester, give prop Romano his debut in a Saracens shirt.
However they have been hit by the loss of key players including Chris Ashton, Owen Farrell and Alex Goode to international duty.
Kameli Ratuvou, Lorenzo Romano, Mouritz Botha and Joel Tomkins are all named in the starting line-up from the side that beat Tigers.
Having returned from international duty with Fiji, Ratuvou makes up the centre pairing with Tomkins.
Prop Rick Reeves and scrum half Ali Price, on loan from Bedford Blues, come on to the bench, alongside hooker Scott Spurling, David Strettle and Jackson Wray.
Sale Sharks: 15.Cameron Shepherd, 14.Charlie Amesbury, 13.Corne Uys, 12.Jordan Davies, 11.Mark Cueto, 10.Danny Cipriani, 9.Dwayne Peel, 8.Richie Vernon, 7. David Seymour (capt.), 6.James Gaskell, 5.Kearnan Myall, 4.Fraser McKenzie, 3.Tony Buckley, 2.Joe Ward, 1.Eifion Lewis-Roberts.
Replacements: 16.Tommy Taylor, 17.Ross Harrison, 18.Vadim Cobilas, 19.Tom Holmes, 20.James Doyle, 21.Will Cliff, 22.Rob Miller, 23.Will Addison
15 Ben Ransom, 14 Duncan Taylor, 13 Joel Tomkins, 12 Kameli Ratuvou, 11 James Short, 10 Nils Mordt (capt.), 9 Ben Spencer, 8 Jono Ross, 7 Andy Saull, 6 Nick Fenton-Wells, 5 Mouritz Botha, 4 George Kruis, 3 Lorenzo Romano, 2 Jamie George, 1 Nick Auterac.
Replacements: 16 Scott Spurling, 17 Rick Reeves, 18 Carlos Nieto, 19 Eoin Sheriff, 20 Jackson Wray, 21 Ali Price, 22 Sam Stanley, 23 David Strettle.
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