The prop was already a doubt for the clash after he suffered an eye injury against England in the final warm-up international.
However Ireland team manager Paul McNaughton has now confirmed the Leinster ace will miss the match - although he should be fit to face Australia six days later.
"The medical advice was that Cian will be not be able to resume contact until this weekend," said McNaughton.
"But he will be fit and available for selection against Australia."
Tom Court or Tony Buckley will now look to replace Healy in the Ireland front row.
Meanwhile the rest of the Irish squad has been given a clean bill of health with Sean O'Brien, Gordon D'Arcy and Rob Kearney all passed fit to face the USA.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
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Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
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The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.