Props Dean Greyling and Werner Kruger will join loose forward Ashley Johnson in making their first appearance in Springboks colours after coach Peter De Villiers named his squad today.
Uncapped scrum-half Charl McLeod will also start on the bench as De Villiers has been forced to test the depth of his squad following a worrying run of injuries ahead of the World Cup.
"The new caps had outstanding Super Rugby seasons and this is an exciting opportunity for them," De Villiers said.
"They have been rewarded for their form and now it's up to them. We have got some new combinations, but there is a lot of potential in this side and the players are hungry for this chance."
John Smit will lead the side with Greyling and Kruger either side of him in a forward pack that is also without experienced second row pair Bakkies Botha and Victor Matfield due to injury.
Lock Flip van der Merwe will therefore get his chance alongside Ulster's Johann Muller.
Despite a depleted forward unit the Springboks' backline features joint Super Rugby top try scorer Bjorn Basson (nine tries) with Lwazi Mvovo no the other wing.
Experienced half-backs Ruan Pienaar and Morne Steyn will pull the strings.
South Africa starting line-up: Gio Aplon; Bjorn Basson, Juan de Jongh, Wynand Olivier, Lwazi Mvovo, Morne Steyn, Ruan Pienaar; Ashley Johnson, Danie Rossouw , Deon Stegmann, Johann Muller, Flip van der Merwe, Werner Kruger, John Smit, Dean Greyling.
Replacements: Chiliboy Ralepelle, CJ van der Linde, Alistair Hargreaves, Jean Deysel, Charl McLeod, Adrian Jacobs, Patrick Lambie.
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