Henson, who replaces Gordon Ross at No 10, is one of six changes made by head coach Lyn Jones to the starting line-up which went down 31-25 to Gloucester last Sunday.
Hooker Dan George and centre James Lewis replace Neil Briggs and Sonny Parker, who both have injuries.
Canadian international Phil Mackenzie comes in on the right wing, with Tom Arscott reverting to full-back and Seb Jewell named on the bench.
Mike Denbee returns to the side following the injury he sustained against Exeter Chiefs and replaces Michael Hills at openside flanker.
Saracens have recalled Charlie Hodgson, David Strettle and James Short.
With Alex Goode, Brad Barritt and Chris Ashton among those rested on rotation, Strettle will make his first start of the season and Owen Farrell will switch to inside centre with Hodgson named at fly-half.
In the forwards, John Smit starts at hooker with second-row George Kruis and flanker Andy Saull both getting their first runs of the season.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The Barbarians are one of the top invitational rugby sides with a long history and classic rugby jersey.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
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Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
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The Lions are ready to get their Australia tour underway. They arrive in Perth on Monday.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.
