Mark Cueto, Danny Cipriani, Kearnan Myall and Richie Vernon will make their first starts of the season following the disappointing opening-day rout against Exeter.
There is also a place for the fit-again Alasdair Dickinson on the bench, however Marc Jones, Cillian Willis and Andy Powell are ruled out through injury.
Saracens have named an unchanged starting XV following last weekend's 40-3 season opening victory over London Irish.
The only changes in McCall's 23-man squad come on the bench where Alistair Hargreaves and Owen Farrell have been named.
Both shaken off minor knocks to be included, with second-row Hargreaves set to make his Aviva Premiership debut should he take to the field.
The other change sees Jared Saunders named among the replacement props on the bench.
Sale: 15 Rob Miller, 14 Will Addison, 13 Johnny Leota, 12 Sam Tuitupou, 11 Mark Cueto, 10 Danny Cipriani, 9 Dwayne Peel, 8 Richie Vernon, 7 David Seymour (capt), 6 James Gaskell, 5 Kearnan Myall, 4 Richie Gray, 3 Vadim Cobilas, 2 Joe Ward, 1 Eifion Lewis-Roberts.Replacements: 16 Tommy Taylor, 17 Alasdair Dickinson, 18 Henry Thomas, 19 Fraser McKenzie, 20 Mark Easter, 21 Will Cliff, 22 Nick Macleod, 23 Corne Uys.
Saracens: 15 Alex Goode, 14 Chris Ashton, 13 Joel Tomkins, 12 Brad Barritt, 11 Chris Wyles, 10 Charlie Hodgson, 9 Richard Wigglesworth, 8 Ernst Joubert, 7 Will Fraser, 6 Kelly Brown, 5 Mouritz Botha, 4 Steve Borthwick (capt), 3 Petrus du Plessis, 2 Schalk Brits, 1 Mako Vunipola. Replacements: 16 Jamie George, 17 Jared Saunders, 18 Carlos Nieto, 19 Alistair Hargreaves, 20 Jackson Wray, 21 Neil de Kock, 22 Owen Farrell, 23 James Short.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
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The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.