The 28-year-old underwent surgery on Wednesday after he injured his anterior cruciate ligament during the LV=Cup clash against Exeter Chiefs last Sunday.
Wigglesworth will miss the whole of next year's Six Nations championship where England will be hoping to defend their title.
Saracens director of rugby Mark McCall told the club's official website: "It's a big blow for Wiggy who has been playing so well for Saracens and has worked so hard in the past 18 months to get himself back in the England side.
"In my opinion he was one of England's stand out players at the World Cup and it's a shame he will miss the Six Nations.
"It's also a blow for us but we are lucky to have two very good players in Neil de Kock and Ben Spencer who have both performed so well this season and because of that, we are not looking to recruit."
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.