The hosts give new signings Charlie Hodgson and Joe Maddock their first starts in the club's colours, coming in at fly-half and on the wing respectively.
Owen Farrell was the hero for Sarries in the last-gasp win against Bath last weekend, but can only manage a place on the bench this time out, while Maddock replaces James Short.
There is one other change to the match-day 23 as Hugh Vyvyan is named on the bench, with the lock looking to build on his all-time Premiership appearance record of 238.
Meanwhile, newly-promoted Worcester will give Alex Crockett his first appearance of the Aviva Premiership season this weekend.
Crockett replaces the suspended Dale Rasmussen, while a new half-back pairing sees Jonny Arr and Andy Goode combine.
In the pack, lock Chris Jones makes his first league start since his summer move to the Warriors, while Bruce Douglas is called into the front row.
Youngster Matt Kvesic is selected at flanker to replace Neil Best, who misses the game with an arm problem.
Prop Ceri Jones could make his Worcester debut off the bench and Sam Betty is also among the replacements as he prepares for a possible Aviva Premiership debut.
Head coach Richard Hill said: "Saracens have got a very good defence and pride themselves on it. They are a very physical and they play a territorial kicking game and don't play too much rugby in their own half.
"We haven't played a team that kicks a lot and our back three have not been tested with high balls or long racking kicks, but they will be tested at Saracens.
"They will kick for territory and our back three will have to make good decisions.
"Saracens also have a very definite attacking strategy. The rugby world know how Saracens play, it is just a question of stopping them. They are very efficient and organised."
Saracens: 15 Alex Goode, 14 David Strettle, 13 Adam Powell, 12 Brad Barritt, 11 Joe Maddock, 10 Charlie Hodgson, 9 Neil de Kock, 8 Ernst Joubert, 7 Andy Saull, 6 Justin Melck, 5 Mouritz Botha, 4 Steve Borthwick (capt), 3 Carlos Nieto, 2 Schalk Brits, 1 Rhys Gill.Replacements: 16 Jamie George, 17 Deon Carstens, 18 Mako Vunipola, 19 Hugh Vyvyan, 20 Will Fraser, 21 Ben Spencer, 22 Owen Farrell, 23 James Short.
Worcester: 15 Errie Claassens, 14 Marcel Garvey, 13 Alex Grove, 12 Alex Crockett, 11 Miles Benjamin, 10 Andy Goode, 9 Jonny Arr, 8 Kai Horstmann (capt), 7 Jake Abbott, 6 Matt Kvesic, 5 Craig Gillies, 4 Chris Jones, 3 Bruce Douglas, 2 Chris Fortey, 1 Matt Mullan.Replacements: 16 Ceri Jones, 17 Ed Shervington, 18 Tevita Taumoepeau, 19 James Percival, 20 Sam Betty, 21 Ollie Frost, 22 Joe Carlisle, 23 Andy Short.
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