Hazell and Peter Buxton provide the wily know-how in a line-up which is a blend of youth and experience.
Tongan international second-row Lua Lokotui makes his debut for the club having flown into the country last Sunday.
There is also a first start of the season for Ryan Mills, the England Under-20 international, following close-season knee surgery.
Gloucester have won one and lost one from their two matches in the competition so far this season, so the game at Franklin's Gardens is a must win if the club is to have a chance of progressing to the semi-final stage.
Northampton: 15 Ben Foden, 14 James Wilson, 13 George Pisi, 12 Luther Burrell, 11 Tom May, 10 Ryan Lamb, 9 Martin Roberts, 8 Rhys Oakley, 7 Phil Dowson, (capt), 6 Samu Monoa, 5 Christian Day, 4 Mark Sorenson, 3 Tom Mercey, 2 Mike Haywood, 1 Alex Waller.
Replacements: 16 Ross McMillan, 17 Soane Tonga'uiha, 18 Ethan Waller, 19 James Craig, 20 Ben Nutley, 21 Lee Dickson, 22 Stephen Myler, 23 Tom Collins.
Gloucester: 15 Martyn Thomas, 14 Steph Reynolds, 13 Henry Trinder, 12 Tim Molenaar, 11 Shane Monahan, 10 Ryan Mills, 9 Dave Lewis; 8 Gareth Evans, 7 Andy Hazell,6 Peter Buxton (capt), 5 Elliott Stooke; 4 Lua Lokotui,3 Dario Chistolini; 2 Koree Britton, 1 Yann Thomas.
Replacements: 16 Tommaso d'Apice, 17 Dan Murphy, 18 Tom Heard, 19 Tom Savage, 20 Ross Moriarty, 21 Jimmy Cowan, 22 Mike Tindall, 23 Rob Cook.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.