After last week's heavy defeat to Exeter, Ross Jones is handed his debut at full-back in place of Barry Davies, and Tom Prydie returns to the right wing with Eli Walker moving to the left flank in place of Kristian Phillips.
Up front Aaron Jarvis comes into the front row in place of Jo Rees, and Ian Evans replaces Richard Kelly in the second row.
Chris Ashton and Ben Foden return to the Saints line-up for the first time since the World Cup, replacing Greig Tonks and Jamie Elliott who started in last week's 36-6 hammering of Saracens.
James Downey replaces Tom May in midfield and Lee Dickson returns at No 9.
Up front Saints coach Jim Mallinder has named most of his big guns, with the likes of Courtney Lawes, Dylan Hartley, Paul Doran Jones, Soane Tonga'uiha all starting.
Ospreys: R Jones, Prydie, John, Parker, Walker, Morgan, Habberfield, Griffiths, Baldwin, Jarvis, Smith, I Evans, King, Lewis, Allen Reps: M Davies, Rees, D Jones, Kelly, O'Toole, Tom Grabham, Price, Davies
Northampton: Foden, Ashton, Armstrong, Downey, Artemyev, Lamb, Dickson, Tonga'uiha, Hartley, Doran-Jones, Lawes, Sorenson, Clark, Wood, Wilson Reps: Haywood, Waller, Mercey, Manoa, Dowson, Roberts, Myler, Clarke
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.