Soane Tonga'uiha and Vasily Artemyev both returned to the club last week after their commitments to Tonga and Russia finished at the end of the World Cup group stage.
England's early departure from New Zealand means that Tom Wood, who starts, Dylan Hartley and Courtney Lawes have also been included in the squad.
There is also a place for Senior Academy back Jamie Elliott, who will make his first start of the season.
Jamie George captains a Saracens side that sees Kameli Ratuvou return to action for the first time in nearly a year after a knee injury.
The Fiji international makes up the centre pairing with Adam Powell with Nils Mordt and Ben Spencer forming the half-back partnership.
In the forwards, Hugh Vyvyan makes his first start of the season in a pack that also includes Deon Carstens, Andy Saull and Justin Melck.
Northampton: Tonks, Elliott, Armstrong, May, Artemyev, Lamb, Roberts, Waller, Haywood, Mercey, Craig, Sorenson, Wood, Nutley, Wilson.
Replacements: Hartley, Tonga'uiha, Doran Jones, Lawes, Eustace, Dickson, Myler, Sempere.
Saracens: Ransom, Maddock, Ratuvou, Powell, Taylor, Mordt, Spencer, Carstens, George, du Plessis, Kruis, Vyvyan, Melck, Saull, Wray.
Replacements: Allen, Auterac, Vunipola, Smith, Fraser, Baldwin, Penney, Short.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The Barbarians are one of the top invitational rugby sides with a long history and classic rugby jersey.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Lions get ready for their matches with this green training jersey. It's what the players wear. Get in the Gear!
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The Lions are ready to get their Australia tour underway. They arrive in Perth on Monday.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.