Murray's inclusion is one of eight changes made by Falcons coach Alan Tait, with Kiwi centre Jeremy Manning also returning following injury.
Wings Rikki Sheriffe and Luke Eves, scrum-half Jordi Pasqualin, front-rowers Darren Fearn and Michael Mayhew and flanker Mark Wilson are all included.
Tait said of Murray's return: "He is one of the best scrummagers in the world, and Mickey Ward has got a smile on his face as front-row coach because he knows like me that great players make a great difference."
Cardiff coaches Gareth Baber and Justin Burnell have placed their faith in a young side for the trip.
Starlets such as Cory Allen, Rhys Patchell and Rhys Downes have been handed their chances to stake first-team claims.
Baber said: "It is a young team that we've selected, but it's full of talent as well and that's what we want to see as coaches."
Newcastle: Goosen, Sheriffe, Uys, Manning, Eves, Gopperth, Pasqualin, Fearn, M. Mayhew, Murray, Townson, van der Heijden, Wilson, Pennycook, Hogg.
Replacements: Graham, Wells, Hall, Swinson, Welch, Chudley, Helleur, Hodgson.
Cardiff: Fish, Mustoe, O Williams, Allen, A Thomas, Patchell, Downes; Trevett, Tyrrell, Harford, Hill, Downes, Jenkins Young, Hamilton.
Replacements: R Williams, Corsi, T Davies, Screech, Shellard, L Jones, L Williams, R Smith.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.