Wasps have already qualified for the last eight but will not be letting up as they try to secure a home quarter-final contest with a win in Wales.
Christian Wade comes back into the starting XV with Tom Varndell, who scored a hat-trick last time out against Mogliano, retained on the opposite wing.
Centre Elliot Daly, prop Zak Taulafo, lock Joe Launchbury and flanker Jonathan Poff all return to the side while the half-back partnership of Nick Robinson and Charlie Davies continues.
The Dragons are unable to qualify for the quarter-finals and have opted for a reshuffle in their pack, with only skipper Lewis Evans keeping his place following last week's defeat to Bayonne.
There are fewer changes among the backs, although Ashleigh Smith comes in for Andy Tuilagi in the centres and Dan Evans replaces Steffan Jones at fly-half.
Wasps: 15 Hugo Southwell (c), 14 Christian Wade, 13 Elliot Daly, 12 Andrea Masi, 11 Tom Varndell, 10 Nick Robinson, 9 Charlie Davies, 8 Billy Vunipola, 7 Jonathan Poff, 6 Sam Jones, 5 Marco Wentzel, 4 Joe Launchbury, 3 Phil Swainston, 2 Tom Lindsay, 1 Zak Taulafo
Replacements: 16 T Rhys Thomas, 17 Tim Payne, 18 Will Taylor, 19 James Cannon, 20 Matt Everard, 21 Joe Simpson, 22 Stephen Jones.
Dragons: 15 Tom Prydie, 14 Will Harries, 13 Adam Hughes, 12 Ashley Smith, 11 Mike Poole, 10 Dan Evans, 9 Jonathan Evans 8 Toby Faletau, 7 Nic Cudd, 6 Lewis Evans (c), 5 Rob Sidoli, 4 Andrew Coombs, 3 Dan Way, 2 Sam Parry, 1 Phil Price.
Replacements: 16 Hugh Gustafson, 17 Owen Evans, 18 Nathan Buck, 19 Ian Nimmo, 20 Ieuan Jones, 21 Wayne Evans, 22 Steffan Jones, 23 Jack Dixon.
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The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
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