The Blues have made four changes from the side which suffered a home defeat to Munster in the RaboDirect PRO12 last time out.
Owen Williams comes in for Dafydd Hewitt in the centres, while Gareth Davies replaces Jason Tovey at fly-half.
In the forwards, Luke Hamilton comes in at flanker for Andries Pretorius, with Robin Copeland swapping to No. 8 and Sam Hobbs replacing Campese Ma'afu at prop.
Wasps, meanwhile, give first starts of the season to Jonah Holmes, Sam Jones, Tinus Du Plessis and Phil Swainston.
Lee Thomas and T Rhys Thomas are both named to start against their former club, while director of rugby Dai Young will also be facing his old side.
Replacements Matt Everard, Will Taylor and Nathan Morris form part of the match-day squad for the first time this season, while Dave Hughes will make his first ever senior appearance if he comes off the bench.
Cardiff Blues: 15 Dan Fish, 14 Tom Williams, 13 Owen Williams, 12 Gavin Evans, 11 Tom James, 10 Gareth Davies, 9 Lewis Jones, 8 Robin Copeland, 7 Josh Navidi (c), 6 Luke Hamilton, 5 James Down, 4 Lou Reed, 3 Taufa'ao Filise, 2 Rhys Williams, 1 Sam Hobbs.
Replacements: 16 Marc Breeze, 17 Nathan Trevett, 18 Ryan Harford, 19 Macauley Cook, 20 Thomas Young, 21 Rob Lewis, 22 Ceri Sweeney, 23 Dafydd Hewitt.
London Wasps: 15 Elliot Daly, 14 Christian Wade, 13 Chris Bell, 12 Lee Thomas, 11 Jack Wallace, 10 Tommy Bell, 9 Jonah Holmes, 8 Billy Vunipola, 7 Sam Jones, 6 Tinus Du Plessis, 5 Marco Wentzel (capt), 4 James Cannon, 3 Phil Swainston, 2 T Rhys Thomas, 1 Simon McIntyre.
Replacements: 16 Nathan Morris, 17 Tim Payne, 18 Will Taylor, 19 Dave Hughes, 20 Matt Everard, 21 Charlie Davies, 22 Tom Varndell, 23 Hugo Southwell.
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The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
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