Wade was especially impressive, to further boost the 20-year-old's England claims, with his two scores catching the eye at the start of each half.
Varndell also reminded of his class as Wasps grabbed back-to-back Aviva Premiership wins following their home success over Worcester last time out.
"Our wings were the major difference between the two sides," Wasps director of rugby Dai Young said.
"Christian was outstanding and Tom wasn't far behind. Christian must be in the frame for England, he is in the Saxons set-up but England are blessed with some high-quality wings and he must carry on the way he is playing to continue to impress them."
Exiles coach Lyn Jones, who saw his side cross through Phil Mackenzie and Stranck Montanella in the second half, agreed with his counterpart's assessment.
"Their back three was the difference in the game," he said.
"They were hugely influential, when they had 50-50 opportunities they took them all."
Wasps could have won by an even greater margin but were careless at times while it did not help that Nicky Robinson missed five from his six attempts.
Young's side looked like they might break the game open at 21-6 but they were unable to shake off the Premiership's newcomers to frustrate their coach.
"We put ourselves under pressure, I wasn't pleased," he said.
"There are a number of things to work on, we struggled up front especially in the second half and our ball retention was very poor.
"We need to play with more composure as we squandered three or four good chances."
Jones was disappointed not to at least take a bonus point from the match.
"The mood in the dressing room is one of disappointment, we threw away a bonus point at the end and they are much sought after," he said.
"The first 20 minutes we went 8-0 down with some poor decision making and we need to be a lot tighter early on. We made too many unforced errors and it loses us points and yards in the Premiership.
"However we were competitive and it was a big effort from our players who all gave 100 per cent."
Wasps scrum-half Joe Simpson was taken from the field on a stretcher at the end of the first half with a knee injury, but Young revealed the problem was not serious.
"Hopefully he will be OK, he will have a scan on his knee but it's not as bad as first feared," he said.
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