Young has made eight alterations in total following the 59-12 win over Mogliano in the Amlin Challenge Cup.
Joe Simpson, Tom Varndell and Lee Thomas start in the backs, with Andrea Masi moving to outside centre.
Billy Vunipola, Marco Wentzel, Joe Launchbury, Zak Taulafo and Tom Lindsay come into the pack, with James Haskell starting on the openside and Ashley Johnson moving to the blindside.
Wasps will come up a familiar face in the London Welsh line-up, with Tom Voyce set to make his debut.
Voyce, who has impressed on trial at the Exiles following his exit from Gloucester, replaces the injured Tom Arscott at full-back.
Voyce's inclusion is one of 12 changes made by head coach Lyn Jones, following the 32-31 win over l Cavalieri Prato in the Amlin Challenge Cup.
Fellow former Wasps Martin Purdy and Seb Jewell and flanker Michael Hills are the only survivors from that team.
London Wasps: 15 Hugo Southwell, 14 Tom Varndell, 13 Andrea Masi, 12 Lee Thomas, 11 Christian Wade, 10 Nick Robinson, 9 Joe Simpson, 8 Billy Vunipola, 7 James Haskell, 6 Ashley Johnson, 5 Marco Wentzel, 4 Joe Launchbury, 3 Zak Taulafo, 2 Tom Lindsay, 1 Tim Payne.
Replacements: 16 T Rhys Thomas, 17 Phil Swainston, 18 Fabio Staibano, 19 James Cannon, 20 Jonathan Poff, 21 Charlie Davies, 22 Tommy Bell, 23 Elliot Daly.
London Welsh: 15 Tom Voyce, 14 Phil MacKenzie, 13 Sonny Parker, 12 Seb Jewell, 11 Nick Scott, 10 Gavin Henson, 9 Tyson Keats, 8 Ed Jackson, 7 Michael Hills, 6 Jonathan Mills (c), 5 Matt Corker, 4 Martin Purdy, 3 Paulica Ion, 2 Neil Briggs, 1 Franck Montanella.
Replacements: 16 Dan George, 17 Tom Bristow, 18 Arthur Joly, 19 Kirill Kulemin, 20 Alfie To'oala, 21 Nick Runciman, 22 James Lewis, 23. Joe Ajuwa.
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