Harlequins will have the services of fly-half Nick Evans available to them when they host Exeter in an Aviva Premiership clash on Saturday.
Evans has been sidelined by an ankle injury but returns to action at the expense of Ben Botica who drops to the bench.
Conor O'Shea has made two further changes to the team that beat Sale last weekend. Skipper Nick Easter moves from number eight into the second row in place of Charlie Matthews with Tom Guest taking over at the back of the scrum.
Exeter enter the encounter with the defending champions on a high after thrashing London Welsh 47-16 last time out.
The victory came at a price though, with prop Hoani Tui, lock Dean Mumm and centre Jason Shoemark all ruled out through injury.
The trio are replaced by Alex Brown, Damian Welch and Phil Dollman respectively.
Harlequins: 15 Ollie Lindsay-Hague, 14 Tom Williams, 13 Matt Hopper, 12 Jordan Turner-Hall, 11 Ugo Monye, 10 Nick Evans, 9 Karl Dickson, 8 Tom Guest, 7 Luke Wallace, 6 Maurie Fa'asavalu, 5 George Robson, 4 Nick Easter (C), 3 James Johnston, 2 Joe Gray, 1 Mark Lambert.
Replacements: 16 Rob Buchanan, 17 Darryl Marfo, 18 Will Collier, 19 Charlie Matthews, 20 Joe Trayfoot, 21 Jordan Burns, 22 Ben Botica, 23 George
Lowe.
Exeter Chiefs: 15 Luke Arscott, 14 Jack Nowell, 13 Sireli Naqelevuki, 12 Phil Dollman, 11 Matt Jess, 10 Gareth Steenson, 9 Haydn Thomas, 8 RichardBaxter, 7 James Scaysbrook, 6 Ben White, 5 Damian Welch, 4 Tom Hayes, 3 Alex Brown, 2 Jack Yeandle, 1 Carl Rimmer.
Replacements: 16 Neil Clark, 17 Ben Moon, 18 Craig Mitchell, 19 James Hanks, 20 Dave Ewers, 21 Will Chudley, 22 Ignacio Mieres, 23 Ian Whitten.
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