Mike Brown will make his 200th appearance for Harlequins in their Heineken Cup clash against Biarritz on Friday night.
George Lowe and Jordan Turner-Hall also renew their centre partnership in midfield.
Tom Guest has been named at number eight and is joined in the back row with captain Chris Robshaw and Maurie Fa'asavalu.
Luke Wallace is named among the replacements, while Ollie Lindsay-Hague will look to make his first appearance in the Heineken Cup.
Meanwhile, Taku Ngwenya returns on the right wing to the Biarritz starting line-up with Iain Balshaw reverting to full-back.
Former London Wasps prop Ben Broster is named at tighthead with Fabien Barcella on the opposite side of the scrum. Imanol Harinodorquy returns at number eight and Raphael Lakafia moves to openside flanker.
They will be looking for revenge for their 40-13 defeat to Harlequins at the Stoop in the Pool opener back in October.
Qualification is a long shot for the French side, who were Heineken Cup finalists in 2006 and 2010. They simply have to beat 'Quins to come into the reckoning as qualifiers for the Amlin Challenge Cup quarter-finals.
Biarritz: 15 Iain Balshaw, 14 Taku Ngwenya, 13 Benoît Baby, 12 Damien Traille, 11 Aled Brew, 10 Jean-Pascal Barraque, 9 Dimitri Yachvili, 8 Imanol Harinordoquy, 7 Raphael Lakafia, 6 Wenceslas Lauret, 5 Pelu Taele, 4 Thibault Dubarry, 3 Ben Broster, 2 Arnaud Heguy, 1 Fabien Barcella.
Replacements: 16 Jean-Philippe Genevois, 17 Thomas Synaeghel, 18 Eugène Van Staden, 19 Erik Lund, 20 Talalelei Gray, 21 Yann Lesgourgues, 22 Julien Peyrelongue, 23 Seremaïa Burotu.
Harlequins: 15. Mike Brown, 14. Tom Williams, 13. George Lowe, 12. Jordan Turner-Hall, 11. Ugo Monye, 10. Nick Evans, 9. Danny Care, 8. Tom Guest, 7. Chris Robshaw (C), 6. Maurie Fa'asavalu, 5. George Robson, 4. Olly Kohn, 3. James Johnston, 2. Joe Gray, 1. Joe Marler.
Replacements: 16. Rob Buchanan, 17. Mark Lambert, 18. Will Collier, 19. Charlie Matthews, 20. Luke Wallace, 21. Karl Dickson, 22. Ben Botica, 23. Ollie Lindsay-Hague.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The Barbarians are one of the top invitational rugby sides with a long history and classic rugby jersey.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Lions get ready for their matches with this green training jersey. It's what the players wear. Get in the Gear!
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The Lions are ready to get their Australia tour underway. They arrive in Perth on Monday.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.