Quins make the long trip north to Manchester with coach Conor O'Shea able to integrate some returning World Cup players back into the fold.
Ross Chisholm returns from injury on the wing.
Joe Gray returns at hooker while flanker Fa'asavalu returns for the first time this season.
Joe Trayfoot will start at number eight in place of Chris York, who faces up to four weeks on the side lines with an ankle injury sustained against London Irish.
The bench sees Nic Mayhew, another close season recruit, return from injury in the front row, where he will be looking to make his debut in place of Mark Lambert, who came off injured against Irish.
Tomas Vallejos is back from the Rugby World Cup, having made his Argentina debut in the tournament.
Meanwhile, Mark Cueto makes his Sale Sharks comeback on Friday.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.