Gloucester welcome back fly-half Freddie Burns.
Burns sat out Gloucester's Challenge Cup outings but he returns as one of five changes made by director of rugby Nigel Davies.
Rob Cook also comes into the backline, with Martyn Thomas making way, while Tom Savage, Nick Wood and Rupert Harden return to the pack.
Captain Jim Hamilton misses out, though, due to injury.
Leicester will be buoyed by the return of vastly experienced duo Geordan Murphy and Louis Deacon for the trip to Kingsholm.
Club captain Murphy has recovered from a knee complaint, while Deacon is promoted from the bench.
Leicester, though, are without Miles Benjamin, Tom Croft, Brett Deacon, Rob Hawkins, Wessel Jooste, Julian Salvi and Richard Thorpe due to injury.
Gloucester: 15 Rob Cook, 14 Charlie Sharples, 13 Mike Tindall (captain), 12 Billy Twelvetrees, 11 James Simpson-Daniel, 10 Freddie Burns, 9 Jimmy Cowan, 1 Nick Wood, 2 Huia Edmonds, 3 Rupert Harden, 4 Tom Savage, 5 Will James, 6 Sione Kalamafoni, 7 Akapusi Qera, 8 Ben Morgan Replacements: 16 Koree Britton, 17 Dan Murphy, 18 Shaun Knight, 19 Peter Buxton, 20 Matt Cox, 21 Dan Robson, 22 Martyn Thomas, 23 Shane Monahan
Leicester: 15 Geordan Murphy (c), 14 Scott Hamilton, 13 Manusamoa Tuilagi, 12 Anthony Allen, 11 Vereniki Goneva, 10 Toby Flood, 9 Ben Youngs, 1 Logovi'i Mulipola, 2 Tom Youngs, 3 Dan Cole, 4 Louis Deacon, 5 Geoff Parling, 6 Steve Mafi, 7 Thomas Waldrom, 8 Jordan Crane
Replacements: 16 George Chuter, 17 Marcos Ayerza, 18 Martin Castrogiovanni, 19 Ed Slater, 20 Graham Kitchener, 21 Sam Harrison, 22 George Ford, 23 Matt Smith
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.