The Aviva Premiership new boys claimed their first top-flight victory back in September when Ed Jackson's late try, coupled with Seb Jewell's conversion, gave them a dramatic 25-24 triumph.
Now the two sides meet again in the LV= Cup, though both will be fielding vastly different line-ups at the weekend.
London Welsh coach Lyn Jones makes six changes to the side that defeated Bath last time out, including recalling Sonny Parker at outside centre in place of Hudson Tonga'uiha.
Nick Runciman comes in for Tyson Keats at scrum-half and Gordon Ross starts at fly-half in place of Gavin Henson. In the forwards, prop Greg Bateman starts and Daniel Browne is named at blindside flanker.
Captain Jonathan Mills moves into the second row in place of Kirill Kulemin, who is away on international duty with Russia.
Former Leicester, Gloucester, Worcester and Newcastle back row forward Adam Balding is amongst London Welsh's replacements, along with James Tideswell.
Exeter, meanwhile, have recalled England Under 20 starlets Jack Arnott, Luke Cowan-Dickie, Sam Hill, Jack Nowell from their Championship clubs where they are dual-registered.
There are also places for Jack Yeandle, Will Carrick-Smith, Joel Conlon and Justin Blanchet in a senior squad for the first time.
London Welsh: 15 Tom Arscott, 14 Tom Voyce, 13 Sonny Parker, 12 Seb Jewell, 11 Nick Scott, 10 Gordon Ross, 9 Nick Runciman,8 Lee Beach. 7 Mike Denbee, 6 Daniel Browne, 5 Martin Purdy, 4 Jonathan Mills (c), 3 Greg Bateman, 2 Neil Briggs, 1 Franck Montanella.
Replacements: 16 Dan George, 17 Tom Bristow, 18 James Tideswell, 19 Adam Brown, 20 Adam Balding, 21 Alex Davies, 22 James Lewis, 23 Joe Ajuwa.
Exeter Chiefs:15 Jack Nowell, 14 Jack Arnott, 13 Nic Sestaret, 12 Myles Dorrian, 11 Mark Foster, 10 Henry Slade, 9 Junior Poluleuligaga (c), 8 Dave Ewers, 7 Justin Blanchet, 6 Joel Conlon, 5 Will Carrick-Smith, 4 Damian Welch, 3 Chris Budgen, 2 Neil Clark, 1 Ben Moon.
Replacements: 16 Jack Yeandle, 17 Luke Cowan-Dickie, 18 Hoani Tui, 19 Jamie Gray, 20 Sam Simmonds, 21 Rob Coote, 22 Sam Hill, 23 Mike Pope.
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