The Chiefs have won three of their last four Aviva Premiership games in front of their own fans, including a resounding 43-6 rout of Sale on the opening weekend of the new season.
However, since then Rob Baxter's side have suffered two narrow defeats on their travels, including going down 25-24 to top-flight new boys London Welsh.
"Yes it was frustrating not to win those games, but that's what it is," said Baxter.
"Every game of Premiership rugby is tough and at the end of the day we came away with something from both those fixtures. Our major aim was to be competitive in every game and we were certainly competitive up in Oxford.
"We would have liked to have won - of course we would have - and did we feel we played as well as could have? Of course we don't. But there is still a reality that in the closing stages we were six points up, but then made a couple of mistakes and the game got away from us."
Their cause this week is not helped by the absence of England flanker Tom Johnson. Craig Mitchell is also missing from their pack, meaning Carl Rimmer and James Phillips are drafted in.
Haydn Thomas is given his first outing of the campaign at scrum-half and the back line is rejigged with Ian Whitten and Phil Dollman trading places.
Meanwhile, scrum-half Neil de Kock will make his 150th appearance for Saracens as they bid to stretch their unbeaten start to the season.
Jamie George gets his first start at hooker as does Duncan Taylor, who is named at outside centre, and Alistair Hargreaves, meaning Steve Borthwick has to make do with a seat on the bench.
After getting 20 minutes of action for Saracens Storm on Monday, Matt Stevens is also in line for his first outing of the season.
Saracens preserved their unbeaten start to the new season with the 9-9 draw with Leicester at Wembley Stadium on Saturday, while they have not lost to Exeter since their first Premiership meeting back in October 2010.
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