Last year's beaten finalists Northampton begin the competition, now in its fourth season, with a home game against Harlequins, while Premiership newcomers London Welsh will make their debut against Exeter.
Elsewhere in the opening round, Ospreys will be up against 2010-11 winners Gloucester, Newport Gwent Dragons go to Bath, London Irish meet Sale, Cardiff take on Wasps and Scarlets go to Worcester.
English clubs have been allocated to the pools depending on their finish in last season's Premiership.
Teams in Pool 1 play teams in Pool 4 and teams in Pool 2 play teams in Pool 3, with the top team from each pool qualifying for the semi-finals.
Pool 1: Harlequins, Exeter, Gloucester, Newport Gwent Dragons.
Pool 2: Leicester, Sale, Worcester, Cardiff.
Pool 3: Saracens, London Irish, Wasps, Scarlets.
Pool 4: Northampton, Bath, London Welsh, Ospreys.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.