The Chiefs make two changes in the pack with Hoani Tui and Simon Alcott coming into the starting line-up, while former Dragons centre Dragons centre Phil Dollman gains a midfield place instead of Jason Shoemark.
However, assistant coach Ali Hepher expects a tough challenge from the Welsh region.
"Looking at the Dragons, you can see they are passionate, their attitude is phenomenal and that they are strong across the board," said Hepher.
"They have some strong ball-carriers and some quick backs, so we will need to be on top of our game to get anything.
"Europe, you can see, is their number one competition. The way they approached the Perpignan game and the level of performance put in that day, you can see there is a real priority for them to do well in Europe."
The Dragons are without skipper Ashley Smith, who suffered a hamstring injury in training this week, so recent signing Andy Tuilagi makes his full debut and flanker Gavin Thomas takes over as captain.
Elsewhere, there is a return for wing Will Harries, while back-row pair Dan Lydiate and Toby Faletau feature after being on Wales duty against Australia last weekend.
Exeter: 15 Luke Arscott, 14 Gonzalo Camacho, 13 Nick Sestaret, 12 Phil Dollman, 11 Matt Jess, 10 Ignacio Mieres, 9 Haydn Thomas, 8 James Phillips, 7 Ben White, 6 Richard Baxter, 5 Chris Bentley, 4 Tom Hayes, 3 Craig Mitchell, 2 Simon Alcott, 1 Hoani Tui.Replacements: 16 Neil Clark, 17 Chris Budgen, 18 John Andress, 19 Alastair Muldowney, 20 Dave Ewers, 21 Patrick Phibbs, 22 Gareth Steenson, 23 Joseph Tatupu.
Dragons: 15 Martyn Thomas, 14 Will Harries, 13 Tom Riley, 12 Andy Tuilagi, 11 Adam Hughes, 10 Steffan Jones, 9 Joe Bedford, 8 Toby Faletau, 7 Gavin Thomas, 6 Dan Lydiate, 5 Robert Sidoli, 4 Adam Jones, 3 Nathan Buck, 2 Lloyd Burns, 1 Phil Price.Replacements: 16 Rhys Buckley, 17 Nathan Williams, 18 Keiron Jenkins, 19 Scott Morgan, 20 Lewis Evans, 21 Wayne Evans, 22 Aled Brew, 23 Jason Tovey.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
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The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
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