Aviva Premiership club Bath have won half of their eight league games this season after suffering a 16-9 loss to London Welsh on Sunday.
The Dragons have endured a season of struggle in the RaboDirect PRO12 with the province winning just two of their eight league fixtures to date.
Bath have given starts to 18-year-old full-back Hallam Amos, 17-year-old centre Jack Dixon and 19-year-old number eight Ieuan Jones along with 21-year-old Bedwas winger Ross Wardle.
The Dragons have been boosted by the return from injury of scrum-half Wayne Evans (back) while Tom Brown has recovered from a knee injury.
The region will be without in-form number eight Tom Brown (knee), lock Rob Sidoli (head), flanker Lewis Evans (head) and prop Phil Price (knee) after they were injured in Glasgow.
Bath: 15 Ollie Devoto, 14 Olly Woodburn, 13 Dan Hipkiss, 12 Matt Banahan, 11 Semesa Rokoduguni, 10 Tom Heathcote, 9 Mark McMillan, 1 Charlie Beech, 2 Brett Sharman, 3 Anthony Perenise, 4 Stuart Hooper (c), 5 Will Spencer, 6 Josh Ovens, 7 Guy Mercer, 8 Simon Taylor.
Replacements: 16 Will Tanner, 17 Ken Dowding, 18 Kane Palma-Newport, 19 Ryan Caldwell, 20 Will Skuse, 21 Chris Cook, 22 Luke Adamson, 23 Richard Lane.
Newport 15 Hallam Amos, 14 Will Harries, 13 Pat Leach, 12 Jack Dixon, 11 Ross Wardle, 10 Steffan Jones, 9 Liam Davies; 1 Owen Evans, 2 Hugh Gustafson, 3 Nathan Buck, 4 Adam Jones, 5 Ian Nimmo, 6 Jevon Groves (c), 7 Nic Cudd, 8 Ieuan Jones.
Replacements: 16 Sam Parry, 17 Nathan Williams, 18 Tim Ryan, 19 Josh Tyler, 20 Tom Brown, 21 Wayne Evans, 22 Ashley Smith, 23 Dan Evans.
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