Royce Cadman and Luke Williams will make their debuts for the hosts in a side captained by scrum-half Joe Bedford.
"There are quite a few new faces on the teamsheet," said Dragons head coach Darren Edwards. "Several of our development and academy players will be out on the park as well as representatives from our Premiership sides."
Bath will also turn to youth for the clash - handing first starts to prop Charlie Beech, lock Will Spencer and wing Olly Woodburn.
Academy hooker Will Tanner and Samoan prop Anthony Perenise are also hoping to take their bows from the replacements' bench.
Fly-half Tom Heathcote partners Mark McMillan in the half-backs, and Matt Banahan goes straight back into the side at centre having returned from the World Cup.
Dragons: M Thomas, Chavhanga, Riley, Robling, Pewtner, M Jones, Bedford (c); N Williams, Buckley, Buck, Cadman, Morgan, Groves, Waters, Ellis.
Replacements: Parry, Gustafson, Jenkins, Sidoli, Brown, Evans, Williams, Jones.
Bath: Cuthbert, Woodburn, Carraro, Banahan, Biggs, Heathcote, McMillan; Beech, Batty, Lilley, Spencer, Attwood, Beattie (c), Mercer, Taylor.
Replacements: Tanner, Catt, Perenise, Caldwell, Skuse, Cook, Roberts, Abendanon.
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