Italy lost to Wales in Cardiff last weekend and will face Scotland in Rome on Saturday.
The Italians go into the encounter at the Stadio Olimpico on the back of a 24-3 loss in Cardiff and, like the Scots, will be determined to avoid the 'wooden spoon'.
Giovambattista Venditti replaces Luke McLean on the right wing while Tommaso Benvenuti will start at centre.
Benetton Treviso's Edoardo Gori replaces Fabio Semenzato at scrum-half while Simone Favaro drops to the bench with flanker Robert Barbieri taking his place in the starting XV.
Aironi lock Marco Bortolami replaces Cornelius Van Zyl to earn his 93rd cap.
Leicester Tigers prop Martin Castrogiovanni has recovered from a fractured rib that saw him miss the last two games and will start this weekend.
Australian-born lock Joshua Furno could make his Six Nations debut this weekend having been included in the squad. The 22-year-old made his Azzurri bow back in August.
Italy have won six of their 18 encounters against Scotland, who have not won in Rome since 2006.
Italy team to face Scotland: A Masi (Aironi Rugby); G Venditti (Aironi Rugby), T Benvenuti (Benetton Treviso), G Canale (Clermont-Auvergne),
Mirco Bergamasco (Racing-Metro Paris); K
Burton (Benetton Treviso), E Gori (Benetton Treviso); A Lo Cicero (Racing Metro-Paris), L Ghiraldini (Benetton Treviso), M Castrogiovanni (Leicester Tigers), Q Geldenhuys (Aironi Rugby), M Bortolami (Aironi Rugby), A Zanni (Benetton Treviso), R Barbieri (Benetton Treviso), S Parisse (Stade Francais).
Replacements: T D'Apice (Aironi Rugby), L Cittadini (Benetton Treviso), J Furno (Aironi Rugby), S Favaro (Aironi Rugby), M Vosawai (Benetton Treviso), T Botes (Benetton Treviso), G Toniolatti (Aironi Rugby), M Rizzo (Benetton Treviso), A Sgarbi (Benetton Treviso).
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.