The Azzurri begin the campaign in Paris on February 4 against Brunel's home nation France before taking on England a week later at Rome's Stadio Olimpico.
Brunel, who replaced Nick Mallett at the helm in November, has included a total of 22 players that competed in last year's World Cup.
However, experienced quartet Salvatore Perugini, Carlos Del Fava, Mirco Bergamasco and Gonzalo Garcia were surprisingly left out of the squad, with Brunel opting to include uncapped youngsters Alberto De Marchi, Luca Morisi, Angelo Esposito and Giovanbattista Venditti instead.
Aironi flanker Mauro Bergamasco returns to the squad having missed last year's entire tournament with a shoulder injury.
Italy begin training in Rome on Sunday.
Italy squad: Martin Castrogiovanni, Lorenzo Cittadini, Alberto De Marchi, Andrea Lo Cicero, Leonardo Ghiraldini, Tommaso D'Apice, Marco Bortolami, Quintin Geldenhuys, Antonio Pavanello, Cornelius Van Zyl, Robert Barbieri, Mauro Bergamasco, Paul Derbyshire, Simone Favaro, Sergio Parisse, Alessandro Zanni, Edoardo Gori, Fabio Semenzato, Kristopher Burton, Luciano Orquera, Tommaso Benvenuti, Gonzalo Canale, Luca Morisi, Alberto Sgarbi, Angelo Esposito, Roberto Quartaroli, Giulio Toniolatti, Giovanbattista Venditti, Andrea Masi, Luke McLean.
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The Barbarians are one of the top invitational rugby sides with a long history and classic rugby jersey.
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The Lions are ready to get their Australia tour underway. They arrive in Perth on Monday.
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The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
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