Saturday's Twickenham Test against Fiji is the precursor to a run of games against southern hemisphere heavyweights Australia, South Africa and New Zealand.
And, after a year spent steadying the ship in the wake of England's poor World Cup, head coach Lancaster has told his players it is time to deliver.
He said: "This challenge against the top three in the world is the strongest one we have faced.
"We are confident. We have prepared well. I've said to the players it's production time now.
"We've got some continuity, we've got some consistency in terms of selection and the coaching team and we've spent some time together. The foundations are strong. Now we want to deliver."
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The Barbarians are one of the top invitational rugby sides with a long history and classic rugby jersey.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Lions get ready for their matches with this green training jersey. It's what the players wear. Get in the Gear!
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The Lions are ready to get their Australia tour underway. They arrive in Perth on Monday.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.