The Northampton pair both suffered knee injuries in the Saints' defeat to Saracens and have returned to their club to undergo further treatment.
While Anthony Allen, Mike Brown, Phil Dowson, Ben Morgan, James Haskell, Jordan Turner-Hall and Ben Youngs have all been released for Premiership duty this weekend.
Worcester prop Matt Mullan and Harlequins lock George Robson, who were initially called up as injury cover for Joe Marler and Lawes, will train with England on Wednesday before returning to their clubs.
However, England head coach Stuart Lancaster insisted those players are still in contention for the Fiji game on 10 November.
"Some return for further treatment from their club and others to get some game time to put a marker down for selection for when we meet again on Sunday after the weekend's games," Lancaster said.
"We will not finalise selection for the Fiji game until after training next Tuesday and so for those going back and playing this is a real opportunity to stake a claim with a really big performance."
Gilbert has released a new line of rugby cleats. The Gilbert Virtuo 8S is part of the exciting new product. Check it out.
The entire All Blacks apparel line has been updated for 2013/14. Check out the New Zealand All Blacks polo.
The Nike Tiempo is a solid rugby cleat and one of few styles still made from full-grain natural leather.
The Gilbert Blitz 8S rugby cleat is a great cleat at a great price of $69.99. Get a new pair of cleats today.
A cool looking all black rugby cleat with the high performance adidas is known for. Get in the Gear!
Wear the crest of the British and Irish Lions on your t-shirt. A great look for the summer.
The All Blacks Performance t-shirt is black with hints of blue from the training jersey. Very Cool.
The New Zealand All Blacks training jersey for 2013/14. Get in the Gear!
The USA Rugby Pro Alternate rugby jersey is perfect for any fan of the Eagles. Get yours to wear during the summer Test matches.
The NEW All Blacks 2013/14 jersey has arrived at World Rugby Shop. Dare to wear the colors of the All Blacks.