Wing Lionel Mapoe and prop Morne Mellett will both make their debut for the Bulls in their Super Rugby opener against the Stormers at Loftus Versfeld on Friday.
The two debutants form part of an otherwise experienced unit which includes two Super Rugby centurions and a host of players with more than 40 caps.
Mapoe has played 23 matches for the Lions and five for the Cheetahs before, whilst Mellett toured with the Bulls last year, but did not play in any matches.
Pierre Spies, who captains the side, is one of 11 players who have 40 caps or more at this level.
Three Springboks, Dean Greyling, Akona Ndungane and Jacques Potgieter were not considered due to injury, whilst Emerging Springbok lock Wilhelm Steenkamp is also out of action of another two weeks due to a shoulder injury.
Bulls: 15 Zane Kirchner, 14 Lionel Mapoe, 13 JJ Engelbrecht, 12 Wynand Olivier, 11 Bjorn Basson, 10 Mornè Steyn, 9 Francois Hougaard, 8 Pierre Spies (captain), 7 Dewald Potgieter, 6 Deon Stegmann, 5 Juandrè Kruger, 4 Flip van der Merwe, 3 Werner Kruger, 2 Chiliboy Ralepelle, 1 Mornè Mellett.
Replacements: 16 Willie Wepener, 17 Frik Kirsten, 18 Grant Hattingh, 19 Arno Botha, 20 Jano Vermaak, 21 Louis Fouchè, 22 Francois Venter.
Date: Friday, February 22
Venue: Loftus Versfeld, Pretoria
Kick-off: 19.10 (17.10 GMT)
Referee: Jaco Peyper (South Africa)
Assistant referees: Rasta Rashivenga (South Africa), Stefan Breytenbach (South Africa)
TMO: Johan Greeff (South Africa)